A Synthesis of 2-(6, 7-Dimethoxy-1, 2, 3, 4-tetrahydro-1-isoquinolylmethyl)-9, 10-dimethoxy-1, 2, 3, 4, 6, 7-hexahydro-11bH-benzo [a] quinolizine (rac-c-Bisnoremetine).

1 , 4 - Phenylenebis [ ( 6 , 7 - dimethoxy - 3 , 4 - dihydroisoquinolin - 2 ( 1 H ) - yl ) methanone ]

The compound named in the title was prepared from N1,N4-diphenethylterephthalamide 1. The resulting bis terephthalamide was subjected to an intramolecular α-amidoalkylation reaction with paraformaldehyde in the presence of heterogeneous catalyst TfOH/SiO2 to obtain 1,4-phenylenebis[(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)methanone]. The structure of the newly synthesized compound was det...

89!$ 7*+ ,!-." /0 1!2!-3 456 )("&'% !"#$1&AB&9!C&C @($&?+ 7 (:

=> L!"M,0 ) -,N#>< $!"O( !> %C>2DE .: 0 3JF 6 7# KH#2 . 6#! "I >3,H9 3(G3H0! %,X 53( W )> A! :&C .6 #! $1"V 5%N9K @ST .=< UJ 53( :P12Q< A! :&C G!2NRK9 A! :8&C 68,3+< :H8V)>%,( . 68#! =YF W)> A! $13XM#! .=< A! %C>2DE ZY[ 5!"9 G!"4'()*+ KF2 1>2 ",`! 53( ^3# >1 G< :9YF _!2` ) $129 $1A39 "+ 53( =]3F 389 ) :928#>U ( W)> K9 6,3+< : HV)>%,( L!>]2030 B()*+ bC! >1 .6 #! KME"P >!"a ) c38! 53...

A 1 2 3 4 5 6 7 8 9 1 0 1 1 m 1500

In paroxysmal nocturnal hemoglobinuria (PNH), little is known about the molecular events leading to the clinical manifestations except for the hemolysis. To unfold the complex pathophysiology, it is necessary to elucidate the nature of the PNH clone. PNH exhibits an acquired stem cell disorder, a clonal expansion of affected cells, concomitant depression of normal hematopoiesis in bone marrow (...

1 1 2 3 4 5 6 7 8

KbP 23 . 1 - 9 . 4 - 6 . 7 - 4 . 4 - 2 .

The gene for the prototype acute phase reactant, Creactive protein, has been isolated from two X phage libraries containing inserted human DNA fragments using synthetic oligonucleotide probes. Nucleotide sequence analysis indicates that after coding for a signal peptide of 18 amino acids and the first two amino acids of the mature protein, there is an intron of 278 base pairs followed by the nu...